Black cumin (Black seed extract) with 5% thymoquinone


Black Seed Extract

A natural remedy to support respiratory health*

Black cumin, or black seed oil, has been use in traditional medicine for its therapeutic benefits for thousands of years. Traditionally, the fixed or essential oil from the seeds were used to address health conditions ranging from supporting healthy liver and kidney function to soothing skin conditions. It is perhaps best known and most well studied for its anti-oxidant, anti-inflammatory and immunomodulatory properties.

The seeds, also known as black cumin seeds or black caraway, come from Nigella sativa, a plant with pale purple, white or blue flowers native to Eastern Europe, the Middle East and Western Asia.[1] The seeds have also been used as a seasoning to flavor curries, pickles and breads in the same way as cumin or oregano.  Thymoquinone is the active ingredient in N. sativa responsible for most of its health benefits. It is a potent antioxidant and anti-inflammatory that is also thought to provide potential support for many health functions.[2]

Princeton Vitamins is pleased to announce the launch of a new formula from N. sativa called Blacqumin® standardized to 5% Thymoquinone, designed to help support healthy respiratory function.*

It is made with a proprietary Black Cumin seed extract called Nigellin™-BCS Amber, which has been shown to suppress release of the most active cytokines and features an identified prostanoid with anti-inflammatory properties, which may possess a supportive effect with regard to asthmatic conditions.[3] Anti-inflammatory and immunomodulating properties are among the most valued in anti-asthma herbal products. According to the 2018 study in Frontiers in Pharmacology, Nigellin showed the highest effects in suppressing the release of cytokines IL-2, IL-6 and PGE2 in T-lymphocytes and also in monocytes hindering the expression on IL-2 and PGE2. These are among the most active cytokines involved in asthmatic conditions. The investigators noted a positive relationship between the TQ level in the preparations and its inhibitory potency on IL-6 and PGE2.

Most black seed extracts are extracted with cheap solvents like hexane or ethylene dichloride and are cold pressed, which will not produce high thymoquinone content. Nigellin is extracted using the super critical fluid extraction process, which extracts compounds from black seed using carbon dioxide instead of a chemical solvent, and is a more environmentally friendly and gentle process to maintain the active constituents of the plant.

Scientific studies

Various studies have demonstrated that the black cumin oil and extract and their active ingredients, particularly thymoquinone, possess antinociceptive and anti-inflammatory effects that support its perception as an analgesic and anti-inflammatory agent.[4]

A recent meta-analysis on N. sativa and thymoquinone, its most abundant constituent, suggests that this compound is responsible for many of the useful effects of the herbal medicine with significant evidence showing its support for hypoglycemic and hypolipidemic function as well as its bronchodilatory effects and note that it warrants further study.[5]

A 2019 study concluded that the antioxidant properties of the seed is gaining regard for its potential role as a dietary supplement with minimal side effects and has promising pharmaceutical and biological properties.[6]

The Nigellin ingredient in Princeton Vitamin’s formula takes this to a new level as it is a solvent-free, supercritical fluid extraction black cumin seed extract that is standardized to contain 5% thymoquinone.

Product Highlights:
  • Standardized to 5% thymoquinone (TQ)
  • Extracted with supercritical fluid extraction
  • 100% natural
  • Vegetarian capsule

Princeton Vitamins Blacqumin with 5% Thymoquinone is now available in select pharmacies, health food stores, Ebay.com, Amazon.com and Princetonvitamins.com.

Nigellin™ is a registered trademark of Sabinsa.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease

Sources:
  1. Benefit of Black Seed oil. Medical news Today. https://www.medicalnewstoday.com/articles/322948
  2. Ibid. Medical News Today
  3. Koshak, AE, Yousif NM et al. Comparative Immunomodulatory Activity of Nigella sativa L Preparations on Profinflammatory mediators. A focus on Asthma. Frontiers In Pharmacology. 2018. Oct. https://www.frontiersin.org/articles/10.3389/fphar.2018.01075/full
  4. Amin B, Hosseinzadeh H. Black Cumin (Nigella sativa) and its active constituent thymoquinone: An overview on the analgesic and anti-inflammatory effects. Plata Med. 2016. Jan;28(1-2):8-16.
  5. Tavakkoli A, Mahdian V, et al. Review on clinical trials of black seeds (Nigella sativa) and its active constituent, thymoquionone. J Pharmacopuncture. 2017 Sept;20(3):179-193.
  6. Timer EM, Tuem KB et al. Nigella sativa, L (Black Cumin): A promising natural remedy for a wide range of illnesses. Evidence-based Complementary and Alternative Medicine. 2019 May. 12:1528635.